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Updated: Jul 6, 2026

Detecting and Characterizing Protein Self-Assembly In Vivo by Flow Cytometry
Published on: July 17, 2019
Isn't self-assembly a misnomer? Multi-disciplinary arguments in favor of co-assembly
1Division of Biomaterials and Bioengineering, University of California, San Francisco, CA 94143, USA. vuk21@yahoo.com <vuk21@yahoo.com>
Abstract:
Self-assembly is a ubiquitous physicochemical phenomenon. It is inherent to molecular recognition effects in the biological domain, and thus presents a basis for understanding the constitution and dynamic organization of living beings. However, it is argued in this paper that the very notion of self-assembly presents an incorrect and misleading one for the physical effects that it stands for. Self-assembly presents a misnomer as each self-assembly process not only depends on, but also includes a certain degree of ordering in the immediate surrounding of the 'self-assembling' entities. Claims are provided to support the idea that every self-assembly process is, in fact, a co-assembly event, as it implies mutual changes and structuring of both the 'self-assembled' system and its nearest surrounding. This point of view is related to the systemic observation that there could be no physical qualities independent on the context of their existence. In order to illustrate that the concept of co-assembly presents only an instance of a more profound and systemic philosophy of life, the examples of the interplay between internal and external factors of development are provided from the fields of quantum and classical physics, biology, evolutionary theory and psychology.
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