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Updated: Jul 6, 2026
11:07
Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Potential functions of plasma steroid-binding proteins
1Departments of Obstetrics and Gynecology, Oncology, and Biochemistry, MRC Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Ontario N6A 4L6, Canada.
Trends in Endocrinology and Metabolism: TEM
|November 1, 1995
Summary
Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) have sophisticated roles beyond transport. New findings reveal targeted actions influencing steroid hormone bioavailability and therapeutic potential.
Area of Science:
- Biochemistry
- Molecular Biology
- Endocrinology
Background:
- Plasma steroid-binding proteins, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), are crucial for transporting steroid hormones and regulating tissue access.
- Recent studies reveal complex functions for CBG and SHBG beyond simple transport.
- Understanding these proteins is key to steroid-hormone dependent diseases.
Purpose of the Study:
- To explore the sophisticated functions of SHBG and CBG.
- To investigate the implications of new findings for steroid hormone action and therapeutic development.
Main Methods:
- Biochemical and molecular analyses of SHBG and CBG and their genes.
- Studies on the biosynthesis and tissue localization of SHBG and CBG.
- Investigation of plasma membrane binding sites and proteinase interactions.
Main Results:
- CBG and SHBG exhibit sophisticated functions beyond blood transport.
- Plasma membrane binding sites for CBG and SHBG exist on target cells.
- Interactions between CBG and proteinases suggest targeted control of steroid hormone action.
Conclusions:
- SHBG and CBG regulate steroid hormone bioavailability and action in a highly selective manner.
- New insights advance understanding of steroid-hormone dependent diseases.
- Findings may influence the design of novel steroid hormone therapeutics.
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