Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Spare Receptors01:30

Spare Receptors

Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.

Regulatory peptides·2004
Same author

Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus.

Neuroscience·2004
Same author

Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1.

Gastroenterology·2001
Same author

Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth.

The Journal of clinical investigation·2001
Same author

Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid.

Clinical endocrinology·2001
Same author

A conserved alpha-helix at the amino terminus of prosomatostatin serves as a sorting signal for the regulated secretory pathway.

The Journal of biological chemistry·2001
Same journal

Mitochondria setting the stage for ferroptosis.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Mitochondria produce lactate to vent redox pressure.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Beyond fat storage: neuronal lipid droplets regulate whole-body metabolism.

Trends in endocrinology and metabolism: TEM·2026
Same journal

HDL resuscitates cells from ferroptosis.

Trends in endocrinology and metabolism: TEM·2026
Same journal

2-Methylbutyrylcarnitine (2MBC).

Trends in endocrinology and metabolism: TEM·2026
Same journal

Decoding growth hormone actions on human growth plate stem cells.

Trends in endocrinology and metabolism: TEM·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

Somatostatin receptors.

Y C Patel1, C B Srikant

  • 1Fraser Laboratories, McGill University, Departments of Medicine and Neurology and Neurosurgery, Royal Victoria Hospital and the Montreal Neurological Institute, Quebec, Canada.

Trends in Endocrinology and Metabolism: TEM
|April 15, 2008
PubMed
Summary
This summary is machine-generated.

Somatostatin (SRIF) receptors (sst) mediate diverse biological effects. This review details their molecular pharmacology, focusing on ligand binding, subtype selectivity, and signal transduction pathways for cell growth and apoptosis.

More Related Videos

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
11:16

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles

Published on: August 7, 2016

Related Experiment Videos

Last Updated: Jul 6, 2026

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
11:16

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles

Published on: August 7, 2016

Area of Science:

  • Endocrinology
  • Molecular Pharmacology
  • Cell Biology

Background:

  • Somatostatin (SRIF) exerts diverse biological effects through a family of five G protein-coupled receptors (sst).
  • These receptors form two subfamilies based on their differential reactivity with SRIF analogues: sst(2,3,5) and sst(1,4).

Purpose of the Study:

  • To review the molecular pharmacology and function of somatostatin receptors.
  • To emphasize ligand-binding domains, subtype-selective analogues, and receptor regulation.
  • To explore signal transduction pathways involved in inhibiting cell secretion, growth, and inducing apoptosis.

Main Methods:

  • Literature review of molecular pharmacology studies.
  • Analysis of receptor-ligand interactions.
  • Examination of signal transduction mechanisms.

Main Results:

  • The sst receptor family exhibits distinct ligand-binding properties and functional responses.
  • Receptor regulation, desensitization, and effector coupling vary significantly between subtypes.
  • Signal transduction pathways mediate SRIF's effects on cell secretion, growth, and apoptosis.

Conclusions:

  • Understanding somatostatin receptor subtypes is crucial for deciphering SRIF's biological roles.
  • Subtype-specific pharmacology offers potential for targeted therapeutic interventions.
  • Further research into signal transduction pathways will elucidate mechanisms of cell growth and apoptosis regulation.