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Updated: Jul 6, 2026
11:17
Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Growth Hormone What is it and what does it do?
1Lutcher Brown Department of Biochemistry, The Whittier Institute for Diabetes and Endocrinology, La Jolla, CA 92037, USA.
Trends in Endocrinology and Metabolism: TEM
|May 1, 1992
Summary
Growth hormone (GH) is not a single substance but a mixture of different forms. Understanding these multiple GH forms is crucial for accurate physiological studies.
Area of Science:
- Endocrinology
- Biochemistry
- Molecular Biology
Background:
- Historically, growth hormone (GH) was considered a singular molecular entity.
- Recent evidence challenges this long-held assumption regarding GH's composition.
Purpose of the Study:
- To highlight the complex nature of growth hormone.
- To emphasize the necessity of accounting for GH heterogeneity in research.
Main Methods:
- Review of existing physiological and biochemical studies on GH.
- Analysis of data supporting the existence of multiple GH isoforms.
Main Results:
- Irrefutable evidence demonstrates that GH exists as a mixture of various molecular forms.
- These distinct GH variants possess different biochemical and physiological properties.
Conclusions:
- Growth hormone heterogeneity is a critical factor in physiological research.
- Accurate evaluation of GH's actions requires consideration of its multiple forms.
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