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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Prorenin in diabetes mellitus.
1Cardiovascular Center, Cornell University Medical College, New York, NY 10021, USA.
Trends in Endocrinology and Metabolism: TEM
|September 1, 1992
Summary
Elevated plasma prorenin levels in diabetes mellitus patients may predict vascular injury. Monitoring prorenin offers insights into disease progression and vascular complications.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Medicine
Background:
- Vascular injury is a significant complication in diabetes mellitus.
- Plasma prorenin elevation has been observed preceding vascular damage in diabetic patients.
Purpose of the Study:
- To explore the predictive value of plasma prorenin levels for vascular injury in diabetes.
- To investigate the role of plasma prorenin in monitoring diabetic vascular disease progression.
Main Methods:
- Analysis of plasma prorenin levels in patients with diabetes mellitus.
- Correlation of prorenin levels with the incidence and progression of vascular injury.
Main Results:
- A rise in plasma prorenin was frequently observed before the onset of vascular injury.
- Plasma prorenin measurements showed potential for predicting vascular complications.
Conclusions:
- Plasma prorenin levels serve as a potential biomarker for predicting vascular injury in diabetic patients.
- Prorenin monitoring can aid in assessing the progression of vascular disease in diabetes mellitus.
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