Bovine placental prolactin-related hormones

The bovine placenta, like that of rodents and primates, synthesizes members of the PRL/GH gene family, which may assist the pituitary hormones or perform unique functions during pregnancy. Bovine placental lactogen (bPL) potentially may act through.three receptors: as an agonist or partial antagonist at the PRL and GH receptors, and via an apparently specific receptor in the endometrium. A large distinct subfamily of diverse primary structure, including bovine PRL-related protein I (bPRP-I), evidently does not act via these receptors. Advances in our understanding of hormone-receptor interactions for this gene family have provided new tools to study the role of these hormones in the successful pregnancy.