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Updated: Jul 6, 2026

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
Pit-1 and hypopituitarism
J S Parks1, E Kinoshita, R W Pfaffle
1Division of Pediatric Endocrinology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Abstract:
The story of Pit-1 and hypopituitarism in humans provides an excellent example of pleiotrophism or multiple phenotypic effects resulting from a single genetic alteration. It shows how defects in this single gene cause the absence o f several pituitary hormones. Three recent articles reviewed here provide examples of different mutations in this homeobox gene encoding a transcriptional activation protein that is vital to the embryologic development, survival, and differentiated function of somatotropes, lactotropes, and thyrotropes.
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