Thyroid hormone regulation of Na,K-ATPase expression
1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Trends in Endocrinology and Metabolism: TEM
|July 1, 1993
Summary
Triiodothyronine (T3) stimulates sodium-potassium transport by increasing Na,K-ATPase biosynthesis. This thyroid hormone action enhances cellular energy expenditure, contributing significantly to thyroid thermogenesis.
Area of Science:
- Molecular Endocrinology
- Cellular Physiology
Background:
- Na,K-ATPase mediates active ion transport crucial for cellular function.
- Thyroid hormones, like triiodothyronine (T3), influence metabolic rate and thermogenesis.
Purpose of the Study:
- To investigate the mechanisms by which T3 stimulates Na,K-ATPase activity.
- To understand the role of T3 in thyroid hormone-mediated thermogenesis.
Main Methods:
- Analysis of Na,K-ATPase subunit gene and mRNA expression.
- Assessment of enzyme activity in response to T3 treatment.
Main Results:
- T3 stimulation increases Na,K-ATPase biosynthesis and mRNA abundance.
- Preferential augmentation of the alpha2 isoform expression in specific tissues.
- T3-induced mRNA increases involve both transcriptional and post-transcriptional regulation.
Conclusions:
- T3 enhances Na,K-ATPase activity through increased subunit synthesis.
- This mechanism contributes significantly to thyroid thermogenesis.
- T3-regulated gene expression involves complex transcriptional and post-transcriptional control.
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