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Amylin in bone conservation current evidence and hypothetical Considerations
M Zaidi1, V S Shankar, C L Huang
1Bone Research Unit, Division of Biochemical Medicine, St. George's Hospital Medical School, London SW 17 ORE, UK.
Trends in Endocrinology and Metabolism: TEM
|October 1, 1993
Summary
Amylin, a pancreatic hormone, plays a role in bone health by inhibiting bone resorption. Lower amylin levels in type-1 diabetes may contribute to bone loss, highlighting its importance in calcium homeostasis.
Area of Science:
- Endocrinology
- Bone Biology
- Calcium Metabolism
Background:
- Amylin is a polypeptide hormone secreted by pancreatic beta cells.
- It is structurally homologous to calcitonin and calcitonin gene-related peptide (CGRP).
- Amylin is known to have anti-insulin effects.
Purpose of the Study:
- To review the effects of amylin on calcium homeostasis.
- To discuss the potential role of amylin in bone conservation.
Main Methods:
- Review of recently described effects of amylin.
- Studies using isolated osteoclasts to investigate amylin's mechanism of action.
Main Results:
- Amylin is a potent hypocalcemic and antiresorptive peptide.
- Amylin inhibits osteoclast motility (Q effect) without affecting cell spread or cytosolic calcium.
- Its action is similar to calcitonin but less potent.
Conclusions:
- Amylin influences calcium homeostasis and bone metabolism.
- Reduced circulating amylin in type-1 diabetes may lead to bone loss.
- Amylin's role in bone conservation warrants further investigation.
