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Updated: Jul 6, 2026
11:17
Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Growth in growth hormone insensitivity
A L Rosenbloom1, J Guevara-Aguirre, R G Rosenfeld
1The Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32608, USA.
Trends in Endocrinology and Metabolism: TEM
|September 1, 1994
Summary
Growth hormone receptor deficiency (GHRD) causes severe insulin-like growth factor-I (IGF-I) deficiency, leading to significantly reduced adult stature. Exogenous IGF-I treatment effectively improves growth and body composition in GHRD patients.
Area of Science:
- Endocrinology
- Genetics
- Pediatric Growth Disorders
Background:
- Primary GH insensitivity due to GH receptor deficiency (GHRD) presents a unique model for understanding severe IGF-I deficiency.
- GHRD impacts postpartum growth, resulting in adult statures significantly below the norm (4-12 SDs).
- Variability in growth outcomes within GHRD populations correlates with biochemical markers of GH activity.
Purpose of the Study:
- To investigate the effects of severe IGF-I deficiency on growth and body composition in GHRD.
- To determine if direct local growth hormone (GH) effects are essential for therapeutic responses.
- To analyze the relationship between GH insensitivity and specific biochemical indicators.
Main Methods:
- Studying patients with primary GH receptor deficiency (GHRD).
- Monitoring growth rates and adult stature in GHRD patients.
- Assessing body composition changes (fat/lean mass).
- Administering exogenous IGF-I to evaluate treatment response.
Main Results:
- Postpartum growth is markedly impaired in GHRD, leading to short stature.
- Exogenous IGF-I administration promotes growth and alters body composition in GHRD patients.
- These responses to IGF-I suggest GH's direct local effects are not required for therapeutic benefits.
Conclusions:
- Severe IGF-I deficiency, as seen in GHRD, is the primary driver of growth failure.
- IGF-I therapy can effectively improve growth and body composition in GHRD.
- The findings highlight the critical role of IGF-I in linear growth and body composition, independent of direct GH action.
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