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Updated: Jul 6, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
10:01

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

Published on: June 23, 2026

An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity

Michael D Aleo1, Colleen M Doshna, Carol A Fritz

  • 1Pfizer Global Research and Development, Drug Safety Research and Development, Groton/New London Laboratories, MS8274-1229, Investigative Toxicology, Eastern Point Road, Groton, CT 06340-8014, USA. michael.d.aleo@pfizer.com

Toxicology and Applied Pharmacology
|April 15, 2008
PubMed
Summary

Cyclosporine A (CSA) impairs whole-body cysteinyl leukotriene (cysLT) elimination, primarily by disrupting hepatobiliary excretion. This leads to increased renal exposure and retention of cysLT, potentially contributing to CSA-induced kidney toxicity.

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