Related Experiment Video
Updated: Jul 6, 2026

Formation of Biomembrane Microarrays with a Squeegee-based Assembly Method
Published on: May 8, 2014
Surface-templated formation of protein microfibril arrays
Ming Sun1, Alina Stetco, Erika F Merschrod S
1Department of Chemistry, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X7.
Abstract:
Ordered arrays of collagen microfibrils form rapidly and spontaneously from a solution of monomers deposited onto a mica substrate. These arrays are well-ordered and apparently continuous over the entire substrate. Correlated atomic force microscope images and Laué diffraction patterns indicate that the protein alignment and microfibril formation is controlled by the crystal orientation of the mica substrate rather than fluid flow or drying effects. This surface-induced mechanism allows for immediate, robust, and reproducible pattern formation.
Related Concept Videos
Assembly of Cytoskeletal Filaments
Formation of Higher-order Actin Filaments
The high-order actin networks...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Formation of Intermediate Filaments
Generation of Straight or Branched Actin Filaments
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
Fibrous Proteins
