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Updated: Jul 6, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
[Familial aggregation of gastric cancer]
1Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Abstract:
Pursuit of the etiologies of familial aggregation of gastric cancer is a particular challenge in an endemic area like Japan. A typical case having truncation-type CDH1 germline mutation, which constitutes an entity of hereditary diffuse gastric cancer, has never been found in Japan or Korea. In addition to candidate gene approaches, painstaking efforts are now in progress using several genome-wide approaches including genome-wide association studies which require a few replications of several thousands of cases and controls. Gene-environmental interactions are also determined to find out the attributes for gastric cancer predisposition.
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