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Identification of the Novel HLA-B*57:212 Allele by Next-Generation Sequencing

Elham Harfouch1, Bénédicte Paré1, Xavier Chamillard1

  • 1EFS Île-de-France, Laboratoire d'Histocompatibilité et d'Immunologie Leuco-Plaquettaire, Créteil, France.

HLA
|August 29, 2026
PubMed

Abstract:

HLA-B*57:212 differs from HLA-B*57:01:01:01 by a single nucleotide substitution in exon 5.

Keywords:
HLA‐B*57:212HLA nomenclaturenext‐generation sequencingnovel alleletransmembrane domain

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Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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