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Allergic Reactions

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Related Experiment Video

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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Published on: September 20, 2019

[Specific immunotherapy and relocation in occupational allergic bakers].

A M Cirla¹, R A Lorenzini, P E Cirla

¹A.O. "lstituti Ospitalieri di Cremona", Unità Operativa Ospedaliera di Medicina del Lavoro (UOOML), Cremona. angelo.cirla@gruppocimal.it

Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia

|April 16, 2008

Summary

Occupational allergy to wheat flour can be treated with subcutaneous specific immunotherapy (SCIT), allowing most bakers to continue their work with improved quality of life and reduced symptoms.

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Area of Science:

Immunology
Occupational Health
Allergology

Context:

Occupational allergy to wheat flour causes rhinitis and asthma in bakery workers.
IgE-mediated immune mechanisms are involved.
Specific immunotherapy (SCIT) using wheat flour extract is now available.

Purpose:

To evaluate the long-term effectiveness of SCIT in allergic bakery workers.
To assess the impact of SCIT on workers' ability to continue their profession.
To determine if SCIT reduces allergic symptoms and improves quality of life.

Summary:

An observational study followed 41 sensitized workers undergoing SCIT for 4+ years without job avoidance.
After 5-10 years, 34/41 workers remained employed with acceptable quality of life and work efficiency.
Both previously treated and currently treated groups showed positive outcomes, with symptom reduction and decreased medication use in the majority.

Impact:

SCIT appears to be a viable treatment for occupational wheat flour allergy.
This immunotherapy can help prevent job relocation and improve workers' lives.
SCIT may be combined with environmental prevention strategies for enhanced workplace safety.