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[In vitro percutaneous absorption of silver nanoparticles]
F Larese Filon1, F D'Agostin, M Crosera
1Unità Clinica Operativa di Medicina del Lavoro, Università degli Studi di Trieste . larese@units.it
Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia
|April 16, 2008
Summary
This study found that silver nanoparticles show negligible skin penetration, even through damaged skin, when applied topically. Further research is needed to fully understand silver nanoparticle absorption.
Area of Science:
- Nanotechnology
- Dermatology
- Toxicology
Context:
- Growing debate on the safety of nanoparticles for topical applications.
- Limited understanding of nanoparticle skin penetration despite known benefits in other fields.
- Need for in vitro studies to assess dermal absorption of nanomaterials.
Purpose:
- To evaluate the in vitro skin penetration of silver nanoparticles (AgNPs).
- To investigate AgNP permeation through both intact and damaged human skin models.
- To quantify potential AgNP migration into deeper skin layers.
Summary:
- Experiments utilized the Franz diffusion cell method with human skin explants.
- Silver nanoparticles (70 microg/cm2) were applied in synthetic sweat for 24 hours.
- Electro Thermal Atomic Absorption Spectroscopy (ETAAS) detected minimal silver (0.2 microg/L) only in damaged skin samples; intact skin showed no detectable levels.
Impact:
- Provides crucial data on the low dermal penetration of silver nanoparticles.
- Suggests negligible risk of systemic exposure from topical AgNP application under tested conditions.
- Highlights the need for continued investigation into nanoparticle-skin interactions and safety assessments.
