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Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Cells and Tissue

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Related Experiment Video

Updated: Jul 6, 2026

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

The dynamic interplay between osteoclasts and the immune system.

Tomoki Nakashima¹, Hiroshi Takayanagi

¹Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan.

Archives of Biochemistry and Biophysics

|April 16, 2008

Summary

This summary is machine-generated.

Osteoimmunology explores the bone-immune system connection. Understanding this interplay, particularly in rheumatoid arthritis, is key for developing new therapies targeting bone and immune diseases.

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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

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Osteoclast Derivation from Mouse Bone Marrow

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Published on: November 6, 2014

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

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Published on: January 27, 2023

Area of Science:

Osteoimmunology
Bone biology
Immunology

Background:

The interplay between bone and immune systems is crucial, as evidenced by studies on arthritis and bone phenotypes in gene-deficient mice.
Osteoimmunology has emerged as a significant field investigating these interactions.
Key molecular pathways, such as RANKL-mediated osteoclastogenesis via NFATc1, link bone remodeling and immune regulation.

Purpose of the Study:

To highlight the importance of the bone-immune system interplay in diseases like rheumatoid arthritis.
To emphasize the role of osteoimmunology in understanding molecular and cellular interactions.
To establish a scientific framework for future therapeutic strategies.

Main Methods:

Investigation of bone phenotypes in mice lacking immune-related genes.
Analysis of molecular pathways involved in osteoclastogenesis and immune cell function.
Review of existing literature on the interactions between bone and immune systems.

Main Results:

Studies in mice lacking immune-related genes reveal significant bone phenotypes.
RANKL stimulates osteoclastogenesis through NFATc1, a key immune regulator.
Enhanced osteoclast activity in rheumatoid arthritis is linked to T helper 17 (T(H)17) cells.

Conclusions:

The field of osteoimmunology is expanding to include diverse molecular and cellular interactions.
Understanding osteoimmunology provides a basis for novel therapeutic approaches.
Targeting the bone-immune axis holds promise for treating related diseases.