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"APUD" cells: fact and fiction
1Oncology Center and Department of Medicine, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.
Trends in Endocrinology and Metabolism: TEM
|March 1, 1990
Summary
Pearse's APUD cell theory explains how small hormone-secreting cells develop from various tissues. These cells differentiate through epithelial pathways present in all embryonic lineages.
Area of Science:
- Endocrinology
- Developmental Biology
- Cell Biology
Background:
- The amine precursor uptake and decarboxylation (APUD) cell theory provides a framework for understanding neuroendocrine cells.
- These cells secrete small polypeptide hormones and originate from diverse embryonic tissues.
Purpose of the Study:
- To elucidate the ontogeny and differentiation pathways of APUD cells.
- To explore the developmental origins of small polypeptide hormone-secreting cells across different tissue types.
Main Methods:
- Review and synthesis of existing literature on APUD cell theory.
- Analysis of developmental biology principles related to epithelial cell differentiation.
Main Results:
- Pearse's APUD cell theory remains relevant for defining the developmental programs of these specialized cells.
- Cells with APUD features can arise via multiple, interconnected pathways of epithelial differentiation.
Conclusions:
- The differentiation of APUD cells is integrated within broader epithelial developmental processes.
- Understanding these pathways is crucial for comprehending the diversity and origin of endocrine and neuroendocrine cells.
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