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Related Experiment Video

Updated: Jul 5, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

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Clinically useful calcitonin assays.

W B Carter¹, H Heath

¹Endocrine Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Trends in Endocrinology and Metabolism: TEM

|July 1, 1990

Summary

Calcitonin assays are crucial for studying C-cell diseases. Newer two-site immunometric assays offer improved sensitivity and specificity over older radioimmunoassays for calcitonin (CT).

Area of Science:

Endocrinology
Immunochemistry
Oncology

Background:

Calcitonin (CT) assays are vital for C-cell research and managing medullary thyroid carcinoma.
Existing radioimmunoassays (RIAs) using polyclonal antisera are generally reliable but can have specificity and sensitivity issues.
Medullary thyroid carcinoma diagnosis and monitoring rely heavily on accurate CT measurements.

Purpose of the Study:

To highlight the limitations of current calcitonin (CT) assays.
To introduce two-site immunometric techniques as a superior alternative for CT measurement.
To emphasize the potential for improved diagnostic and monitoring capabilities.

Main Methods:

Review of existing radioimmunoassay (RIA) techniques for calcitonin (CT).

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Discussion of the principles and advantages of two-site immunometric assays.

Comparison of sensitivity, specificity, and turnaround time between RIA and immunometric methods.

Main Results:

Classical competitive-binding radioimmunoassays for CT can exhibit problems with specificity and sensitivity.
Two-site immunometric techniques demonstrate potential for enhanced sensitivity and specificity.
Improved assay performance can lead to faster and more reliable patient follow-up.

Conclusions:

Two-site immunometric assays represent a significant advancement over traditional RIAs for calcitonin (CT).
These improved assays hold promise for better diagnosis and management of conditions like medullary thyroid carcinoma.
Further adoption of immunometric techniques is recommended for calcitonin (CT) analysis.