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Intrathyroidal iodine heterogeneity of iodocompounds and kinetic compartmentalization

H Studer1, H Gerber

  • 1University Clinic of Internal Medicine, Laboratory of Endocrinology, Inselspital, 3010 Bern, Switzerland.

Trends in Endocrinology and Metabolism: TEM
|January 1, 1991
PubMed

In the normal thyroid, but not necessarily in the goitrous gland, the bulk of iodine is bound to thyroglobulin. Even in the normal thyroid-and much more so in goiters-iodine is contained in many different compartments with widely differing kinetics, biochemical composition, localization, and physiologic significance. Any change of thyroid function profoundly affects intrathyroidal iodine kinetics and produces a redistribution of stored iodine. This must be taken into account whenever the impact of a global change in intrathyroidal iodine stores on thyroid function and growth is studied in vivo.

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