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Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...

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Related Experiment Video

Updated: Jul 5, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

[The cornea: stasis and dynamics].

Teruo Nishida1

  • 1Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube-City, Japan.

Nippon Ganka Gakkai Zasshi
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Maintaining corneal transparency and shape is crucial for good vision. This review explores corneal homeostasis mechanisms and new treatments for diseases like persistent epithelial defects and corneal ulcers, focusing on network systems and drug development.

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A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe

Published on: June 12, 2012

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Last Updated: Jul 5, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
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A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe
14:58

A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe

Published on: June 12, 2012

Area of Science:

  • Ophthalmology and Vision Science
  • Cell Biology and Molecular Mechanisms
  • Tissue Engineering and Regenerative Medicine

Context:

  • The cornea's transparency and refractive shape are vital for vision, maintained by dynamic tissue, cellular, and molecular processes.
  • Corneal homeostasis relies on complex network systems involving cell-cell interactions, extracellular matrix, cytokines, and neural factors.
  • Disruptions in these network systems can lead to pathological conditions such as persistent epithelial defects and corneal ulcers.

Purpose:

  • To review the mechanisms underlying corneal homeostasis and the maintenance of corneal transparency and shape.
  • To discuss the disruption of corneal network systems leading to diseases like persistent epithelial defects and corneal ulcers.
  • To explore the development of novel therapeutic strategies and drugs for various corneal diseases.

Summary:

  • Corneal transparency and shape are maintained by intricate network systems involving cellular and molecular interactions.
  • Persistent epithelial defects and corneal ulcers arise from disruptions in these network systems.
  • New treatments are being developed, including fibronectin eyedrops, peptide-based therapies for neurotrophic keratopathy, and drugs like triptolide for corneal ulcers.

Impact:

  • Advances in understanding corneal network systems offer insights into disease pathogenesis.
  • Development of targeted therapies holds promise for improving treatment outcomes for challenging corneal conditions.
  • This research paves the way for innovative drug development, potentially reducing the long-term burden of corneal diseases.