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Human skin buffering capacity: an overview.

Jacquelyn Levin1, Howard Maibach

  • 1Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ 85310, USA. jlevin@hotmail.com

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|April 17, 2008
PubMed
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Skin acidity, measured by pH and buffering capacity, is key to skin health. This review explores epidermal components responsible for maintaining the skin's acid/alkali resistance and neutralization capacity.

Area of Science:

  • Dermatology and Skin Physiology

Background:

  • Skin surface acidity is crucial for maintaining a healthy skin barrier.
  • Skin's resistance to acidic/alkaline challenges is defined as its buffering capacity.
  • Understanding epidermal buffering mechanisms is vital for skin health research.

Purpose of the Study:

  • To review studies on the mechanisms of epidermal buffering capacity.
  • To identify key epidermal components contributing to acid/alkali resistance.
  • To elucidate the factors responsible for the skin's neutralization capacity.

Main Methods:

  • Literature review of studies investigating epidermal buffering capacity.
  • Analysis of experimental data from acidic/alkaline aggression tests on skin.
  • Identification and evaluation of proposed mechanisms for epidermal buffering.

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Main Results:

  • The epidermis possesses a significant capacity to resist changes in pH when exposed to acidic or alkaline conditions.
  • Specific cellular and extracellular components within the epidermis are primarily responsible for this buffering effect.
  • The interplay of these components determines the overall acid/alkali resistance and neutralization capacity of the skin.

Conclusions:

  • The epidermis exhibits robust buffering capabilities essential for maintaining skin homeostasis.
  • Key epidermal components, yet to be definitively identified in this review, play a critical role in acid/alkali resistance.
  • Further research is needed to pinpoint the exact mechanisms and components governing epidermal buffering ability.