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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Interfacial kinetics effects on transdermal drug delivery: a computer modeling.

Malcolm M Q Xing1, Ning Pan, Wen Zhong

  • 1Department of Biological Systems Engineering, University of California, Davis, CA 94143-0989, USA.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
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PubMed
Summary

This study developed a finite-element model to simulate drug diffusion through skin layers, revealing how interphases impact transdermal drug delivery and enabling better patch design.

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Published on: February 23, 2018

Area of Science:

  • Biomedical Engineering
  • Pharmaceutical Sciences
  • Computational Modeling

Background:

  • Percutaneous permeation is crucial for transdermal drug delivery.
  • The physics of drug diffusion across the skin's layers, particularly interphases, are not fully understood.

Purpose of the Study:

  • To develop a computational model simulating drug diffusion through the skin.
  • To investigate the influence of interphases on transdermal drug delivery and absorption.
  • To provide a tool for optimizing drug delivery systems.

Main Methods:

  • Finite-element method (FEM) was employed to create a contact algorithm.
  • An interphase element was incorporated to model barrier effects on drug diffusion.
  • A multilayered skin model (patch, stratum corneum, viable epidermis) was simulated.

Main Results:

  • Interphase transfer coefficients directly correlate with drug concentration and flux.
  • Simulation results indicate potential for optimizing drug diffusion control.
  • Partition coefficients and interphase barriers can be integrated into the model.

Conclusions:

  • The FEM algorithm handles complex geometries intractable for analytical methods.
  • The model, validated with experimental data, can realistically predict drug delivery and distribution.
  • This approach can aid in designing improved transdermal patches and drugs.