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A new approach to stabilize complementary complexes formed by short oligonucleotides and their derivatives
1Institute of Bioorganic Chemistry, Siberian Division, Academy of Sciences of the USSR, Novosibirsk.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
A proposed approach to stabilize complementary complexes is based on the stabilizing effect of oligonucleotide derivatives bearing polyaromatic residues on the adjacent short oligonucleotides if their recognition sites make a tandem on the target. This approach has been used to enhance efficiency and specificity of site-specific modification of nucleic acids.