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Related Experiment Video

Updated: Jul 5, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Menstrual phase effects on smoking relapse.

Sharon S Allen1, Tracy Bade, Bruce Center

  • 1Tobacco Use Research Center of the University of Minnesota, Minneapolis, MN 55455, USA. allen001@umn.edu

Addiction (Abingdon, England)
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Women attempting to quit smoking during the follicular phase had higher relapse rates than those in the luteal phase. Menstrual cycle phase significantly impacts smoking cessation success in women.

Related Experiment Videos

Last Updated: Jul 5, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Area of Science:

  • Reproductive Endocrinology
  • Addiction Medicine
  • Behavioral Science

Background:

  • Smoking cessation remains a significant public health challenge.
  • Understanding factors influencing cessation success in women is crucial.
  • The menstrual cycle, with its hormonal fluctuations, may influence smoking behavior.

Purpose of the Study:

  • To investigate whether the menstrual phase at the time of quitting affects smoking relapse rates in women.
  • To determine if initiating a smoking cessation attempt during the follicular (F) phase versus the luteal (L) phase yields different outcomes.

Main Methods:

  • A randomized controlled trial involving 202 women attempting to quit smoking.
  • Participants were assigned to initiate their quit attempt in either the follicular or luteal menstrual phase.
  • Relapse was assessed by time to relapse and point prevalence over 26 weeks.

Main Results:

  • Women quitting in the follicular phase showed significantly higher relapse rates compared to those quitting in the luteal phase.
  • At 14 days post-quit, 84% of the follicular group relapsed versus 65% of the luteal group (OR=2.87).
  • At 30 days, 86% of the follicular group relapsed compared to 66% of the luteal group (OR=3.18).

Conclusions:

  • Initiating smoking cessation in the follicular phase is associated with less favorable outcomes.
  • Ovarian hormones, influenced by menstrual phase, may play a role in women's smoking cessation success.
  • These findings suggest personalized smoking cessation strategies may be beneficial for women.