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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
Small RNA guides for de novo DNA methylation in mammalian germ cells
Alexei A Aravin1, Déborah Bourc'his
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Genes & Development
|April 17, 2008
Abstract:
Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (908-917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.
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