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Synthesis and properties of modified oligonucleotides
R L Letsinger1, R A Alul, F Farooqui
1Department of Chemistry, Northwestern University, Evanston, IL 60208.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
Phosphorothioate oligonucleotide analogs conjugated to cholesteryl by a neutral, 6 atom linker are more effective inhibitors of HIV-1 in cell culture than the corresponding analogs conjugated via a phosphorothioate group. The antiviral activity correlates with the hydrophobic character of the oligonucleotide. Some new synthetic methodology is also discussed.