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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
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Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

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Related Experiment Video

Updated: Jul 5, 2026

Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy
13:48

Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy

Published on: May 29, 2012

Emerging non-invasive Raman methods in process control and forensic applications.

Neil A Macleod1, Pavel Matousek

  • 1Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, UK.

Pharmaceutical Research
|April 17, 2008
PubMed
Summary
This summary is machine-generated.

Emerging Raman spectroscopy techniques, Spatially Offset Raman Spectroscopy (SORS) and Transmission Raman Spectroscopy (TRS), enable non-invasive sub-surface analysis. These methods are valuable for process control and forensic science, offering new capabilities for detecting counterfeit drugs and analyzing pharmaceuticals.

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Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy
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Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy

Published on: May 18, 2011

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Last Updated: Jul 5, 2026

Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy
13:48

Non-contact, Label-free Monitoring of Cells and Extracellular Matrix using Raman Spectroscopy

Published on: May 29, 2012

Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy
15:04

Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy

Published on: May 18, 2011

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Forensic Science

Background:

  • Non-invasive analysis is crucial for process control and forensic applications.
  • Traditional methods often require sample preparation or destructive testing.
  • Sub-surface probing offers advantages for analyzing intact materials.

Purpose of the Study:

  • To review emerging Raman spectroscopy techniques for non-invasive, sub-surface analysis.
  • To discuss the new capabilities of Spatially Offset Raman Spectroscopy (SORS) and Transmission Raman Spectroscopy (TRS).
  • To present application examples in process control and forensic science.

Main Methods:

  • Review of Spatially Offset Raman Spectroscopy (SORS).
  • Review of Transmission Raman Spectroscopy (TRS).
  • Discussion of non-invasive, sub-surface probing capabilities.

Main Results:

  • SORS and TRS offer novel non-invasive, sub-surface analysis.
  • These techniques allow detection of counterfeit drugs through packaging.
  • Rapid quantitative analysis of pharmaceutical bulk content is achievable without sub-sampling.

Conclusions:

  • SORS and TRS are powerful emerging Raman techniques.
  • These methods have significant potential in process control and forensic applications.
  • Non-invasive sub-surface analysis enhances safety and efficiency in various fields.