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Related Experiment Videos

[Calcitonin.].

C Maier1

  • 1Schmerzsprechstunde der Zentralen Abteilung für Anaesthesie, Klinikum der Universität, Schwanenweg 21, D-2300, Kiel 1.

Schmerz (Berlin, Germany)
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Calcitonin shows promise for specific pain conditions like tumor pain and phantom limb pain, but its long-term effectiveness is limited by side effects and tolerance. Further clinical studies are needed to fully determine its value in pain management.

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Area of Science:

  • Pharmacology
  • Pain Management

Context:

  • Calcitonin's central antinociceptive effects are established in animal models.
  • Clinical evidence for calcitonin in human pain therapy remains limited.

Purpose:

  • To evaluate the clinical efficacy of calcitonin in various pain conditions.
  • To assess the appropriate dosage and administration route for calcitonin in pain management.

Summary:

  • Calcitonin may supplement opiate therapy for bone tumor pain and nerve infiltration pain.
  • It can be used alongside physical therapy for algodystrophy, with sympathetic blockade for severe cases.
  • Calcitonin is effective for phantom limb pain, sometimes as a sole analgesic, and for refractory stump pain.
  • Intravenous administration of 1.5-3 IU/kg daily is recommended; treatment should cease if no immediate effect.

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  • While serious adverse effects are rare, dose-dependent side effects are common and can be distressing.
  • Long-term use is limited by disadvantages and the 'escape' phenomenon, restricting its overall analgesic value.

    • Impact:

    • Provides guidance on specific indications for calcitonin in pain management.
    • Highlights the importance of appropriate dosage and administration for potential efficacy.
    • Identifies limitations and side effects that impact the long-term utility of calcitonin as an analgesic.