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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
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Wnt signaling in somite development.

Poongodi Geetha-Loganathan1, Suresh Nimmagadda, Martin Scaal

  • 1Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstrasse 17, D-79104 Freiburg, Germany. poongo_3@yahoo.com

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
|April 18, 2008
PubMed
Summary
This summary is machine-generated.

Wnt signaling is vital for vertebrate somitogenesis, guiding the rhythmic development of somites, which form muscles, vertebrae, and dermis. This review details Wnt

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Area of Science:

  • Developmental biology
  • Molecular signaling
  • Vertebrate embryogenesis

Background:

  • Somites are transient, segmented mesodermal structures crucial for vertebrate development.
  • Somite formation involves a precise, rhythmic process of segmentation, epithelialization, and differentiation.
  • Wnt signaling pathways are implicated in regulating multiple stages of somite development.

Purpose of the Study:

  • To provide an overview of Wnt signaling's role in somite development.
  • To summarize current knowledge on Wnt signaling events during somitogenesis and the formation of somite derivatives.
  • To highlight the importance of Wnt pathways in mesodermal tissue formation.

Main Methods:

  • Literature review of existing research on Wnt signaling and somite development.
  • Synthesis of current understanding of molecular mechanisms.
  • Analysis of key signaling events and their impact on cell fate.

Main Results:

  • Wnt signaling influences key steps including paraxial mesoderm segmentation and somite patterning.
  • Aberrant Wnt signaling disrupts somite formation and subsequent tissue differentiation.
  • Specific Wnt ligands and receptors are critical for regulating the timing and extent of somite development.

Conclusions:

  • Wnt signaling is a central regulator of vertebrate somitogenesis.
  • Understanding Wnt pathways is essential for deciphering the development of skeletal muscles, vertebrae, and dermis.
  • Further research into Wnt signaling dynamics can illuminate mechanisms of developmental disorders.