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The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Goiter

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

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Updated: Jul 5, 2026

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Published on: April 21, 2023

Microfilaria in thyroid gland nodule.

Monisha Chowdhary¹, Sabeena Langer, Meenu Aggarwal

¹Department of Patholgy, Lady Hardinge Medical College, New Delhi, India.

Indian Journal of Pathology & Microbiology

|April 18, 2008

Summary

Microfilaria in the thyroid gland is rare, often linked to goiter or tumors. This case highlights microfilaria found in a solitary thyroid nodule via fine needle aspiration cytology.

Area of Science:

Endocrinology
Parasitology
Cytopathology

Background:

Filariasis is a significant public health concern in the Indian subcontinent.
Thyroid microfilaria is an uncommon clinical observation.

Observation:

A solitary thyroid nodule was investigated using fine needle aspiration cytology.
Microfilaria were identified within the thyroid nodule specimen.

Findings:

The cytological examination revealed the presence of microfilaria in the thyroid nodule.
This finding is unusual, as most reported thyroid microfilaria cases are associated with goiter or neoplasms.

Implications:

This case expands the spectrum of thyroidal filariasis presentations.

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Highlights the importance of cytopathology in diagnosing rare parasitic infections of the thyroid gland.