Related Experiment Videos
Splenic lymphoma with villous lymphocytes
Ritu Gupta1, Shano Naseem, Shawgi Sukumaran
1Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow - 226 014, India. drritugupta@gmail.com
Indian Journal of Pathology & Microbiology
|April 18, 2008
Summary
Splenic lymphoma with villous lymphocytes (SLVL) is a rare cancer. This case highlights diagnostic challenges in differentiating SLVL from other leukemias like CLL.
Area of Science:
- Hematology
- Oncology
Background:
- Splenic lymphoma with villous lymphocytes (SLVL) is a rare lymphoid neoplasm, representing less than 1% of cases.
- It is the leukemic form of splenic marginal zone lymphoma (SMZL).
- SLVL typically presents with splenomegaly, moderate lymphocytosis, and characteristic villous lymphocytes in peripheral blood.
Observation:
- A case of SLVL in a 56-year-old male is presented.
- The patient exhibited extremely high leukocyte counts and massive splenomegaly.
- Few leukemic cells with subtle villous projections were noted on peripheral blood smear.
Findings:
- The case presented diagnostic challenges due to atypical features.
- SLVL can be mistaken for other chronic lymphoproliferative disorders such as chronic lymphocytic leukemia (CLL) and hairy cell leukemia.
- Accurate differentiation is crucial for appropriate patient management.
Implications:
- This case underscores the importance of recognizing diagnostic pitfalls in SLVL.
- Awareness of subtle presentations is key for correct diagnosis.
- Proper differentiation from other leukemias ensures targeted therapy and improved patient outcomes.
Related Concept Videos
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:27Histology of the Small Intestine
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...