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Updated: Jul 5, 2026

Murine Fetal Echocardiography
Published on: February 15, 2013
Fetal cardiocentesis: a review of indications, risks, applications and technique
Albert P Sarno1, R Douglas Wilson
1Maternal-Fetal Medicine Section, Perinatal Center, St. Luke's Hospital and Health Network, Bethlehem, Pa 18015, USA. apsarno@earthlink.net
Insights
Fetal cardiocentesis offers prenatal diagnosis and treatment options when other methods fail. However, its higher risk compared to cordocentesis necessitates careful consideration of benefits versus potential harm.
Area of Science:
- Perinatology
- Fetal Medicine
- Interventional Cardiology
Background:
- Fetal cardiocentesis is an invasive procedure.
- Its applications in prenatal diagnosis and therapy are evolving.
- Comparison with cordocentesis is essential for risk-benefit assessment.
Purpose of the Study:
- To review the indications for fetal cardiocentesis.
- To explore its diverse applications in fetal medicine.
- To detail the technique of fetal cardiocentesis.
Main Methods:
- Systematic review of published literature.
- Utilized PubMed database for case reports and series.
- Focused on fetal cardiocentesis procedures.
Main Results:
- Fetal cardiocentesis facilitates prenatal diagnosis, intravascular therapy, multifetal reduction, and in utero treatment of congenital heart disease.
- It serves as an alternative when cordocentesis is not feasible.
- Procedure-associated risks are higher than with cordocentesis.
Conclusions:
- Fetal cardiocentesis is a viable option for fetal intravascular access and therapeutic interventions.
- It is particularly useful when cordocentesis is unsuccessful or impossible.
- The potential benefits must demonstrably outweigh the procedure-associated risks.
Objectives:
To review the indications, applications and technique of fetal cardiocentesis.
Methods:
Review of published case reports and case series of fetal cardiocentesis utilizing the PubMed search engine of the National Library of Medicine.
Results:
Case reports and case series demonstrate that fetal cardiocentesis may be an alternative method by which to facilitate prenatal diagnosis, intravascular therapy, multifetal and selective fetal reduction and in utero therapy of congenital heart disease. However, procedure-associated risk is higher than with cordocentesis and may limit use of this procedure.
Conclusions:
Fetal cardiocentesis may be a reasonable option to obtain fetal intravascular access and facilitate therapeutic interventions when cordocentesis fails or is not feasible. However, expected benefit must clearly outweigh the procedure-associated risk.
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