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Updated: Jul 5, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
Molecular epidemiology of Mycobacterium tuberculosis in an urban area in Japan, 2002-2006
A Ohkado1, M Nagamine, Y Murase
1Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan. ohkadoa@jata.or.jp
Setting:
Shinjuku City, Tokyo, Japan.
Objective:
To evaluate the status of transmission of Mycobacterium tuberculosis in Shinjuku City to allocate resources efficiently and effectively for a successful tuberculosis (TB) control programme.
Design:
Observational descriptive study combining the genotype data of M. tuberculosis with TB patient profiles.
Results:
The genotype clustering rate was significantly higher in males (adjusted odds ratio [aOR] 1.94, 95%CI 1.04-3.65, P = 0.038), patients aged <40 years (aOR 2.09, 95%CI 1.17-3.71, P = 0.012) and the homeless (aOR 2.72, 95%CI 1.42-5.20, P = 0.002), and was lower for the foreign-born (aOR 0.21, 95%CI 0.06-0.76, P = 0.017). Among 45 genotype clusters containing 152 TB patients, 26 clusters containing 102 patients (67.1%) were composed of a mix of homeless and non-homeless patients. One of the mixed clusters included an 8-month-old infant born in Japan.
Conclusion:
The study revealed that M. tuberculosis transmission occurred more frequently among the homeless than in non-homeless persons. However, transmission by casual contact between the homeless and the general population was also shown to occur.
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