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[Mucosal involvement in lymphomatoid papulosis: four cases]
1Service de dermatologie, centre hospitalier universitaire de Caen, avenue Georges-Clémenceau, 14033 Caen cedex, France.
Recurrent oral ulcerations can be a sign of lymphomatoid papulosis (LyP), a rare skin condition. This study reports four new cases of oral LyP, finding the mouth is a common site and prognosis is unaffected by location.
Area of Science:
- Dermatology
- Oncology
- Pathology
Context:
- Lymphomatoid papulosis (LyP) is a CD30+ cutaneous lymphoproliferative disorder.
- Characterized by benign eruptions with malignant histological features.
- Mucosal LyP is rare, with fewer than 10 previously reported cases.
Purpose:
- To report four new cases of mucosal lymphomatoid papulosis.
- To highlight characteristic features of LyP lesions in the oral and genital mucosa.
- To discuss the clinical presentation and potential implications for diagnosis and prognosis.
Summary:
- Four cases of mucosal LyP (three women, one man) are presented, with oral lesions in all cases and genital involvement in one.
- Lesions occurred before, after, or in isolation from cutaneous eruptions.
- Pathological features included types A and C; lymphoma was excluded. Methotrexate treatment showed potential benefit.
Impact:
- Recurrent oral ulcerations should be considered potential mucosal manifestations of LyP.
- The oral site does not appear to influence the prognosis of LyP.
- Adds to the limited literature on mucosal LyP, aiding in recognition and management.
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