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Design of oligonucleotides for sequence-specific triple-helix formation. Properties of oligonucleotides containing
M Shimizu1, H Inoue, E Ohtsuka
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
Homopyrimidine-homopurine sequences are targeted by homopyrimidine oligodeoxynucleotides to form triple helix structure. Xanthine was introduced to the third strand of pyrimidine-rich 15-mer oligodeoxy-nucleotides to recognize a cytosine in the purine strand in a homopyrimidine-homopurine duplex target.