Related Experiment Videos
Novel method of synthesis of oligo(deoxyribonucleoside phosphorothioates)
1Polish Academy of Sciences, Department of Bioorganic Chemistry, Lódź.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
The syntheses of 5'-O-DMT base-protected nucleoside 3'-O-[2-thio-1.3.2-oxathia-phospholanes] (1) and their subsequent reactions with nucleosides bound via 3'-oxygen to solid support, performed in the presence of DBU, formulate the basis to new methodology of preparation of title compounds--OligoS. Moreover separation of 1 into diastereoisomeric species allows the preparation of OligoS in stereocontrolled manner.