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[Autoimmune phenomena in the elderly].

L Pérez1, C Rodríguez, J A Sepúlveda

  • 1Departamento Preclínicos Facultad de Medicina (División Ciencias Médicas Occidente), Universidad de Chile, Santiago.

Revista Medica De Chile
|March 1, 1991
PubMed
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Autoimmune markers like antinuclear antibodies are more prevalent in elderly individuals over 65. This study found significantly higher positive titers in older adults compared to younger controls.

Area of Science:

  • Immunology
  • Gerontology

Background:

  • Autoimmune phenomena can manifest in various age groups.
  • The prevalence of autoimmune markers in the elderly population requires further investigation.

Purpose of the Study:

  • To determine the prevalence of specific autoantibodies in elderly individuals without clinical signs of autoimmune disease.
  • To compare autoantibody titers in the elderly to a younger control group.

Main Methods:

  • Sera analysis from 102 subjects aged over 65.
  • Testing for antinuclear antibodies, anti-smooth muscle antibodies, rheumatoid factor, and anti-mitochondrial antibodies.
  • Comparison with a control group of healthy younger adults.

Main Results:

  • 18.6% of elderly subjects had positive antinuclear antibodies.

Related Experiment Videos

  • 16.6% tested positive for anti-smooth muscle antibodies, and 11.8% for rheumatoid factor.
  • These autoantibody titers were significantly higher (p < 0.0001) in the elderly group compared to controls.

    • Conclusions:

    • The elderly population exhibits a higher prevalence of certain autoimmune markers.
    • These findings suggest an increased occurrence of subclinical autoimmune phenomena in aging individuals.