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Updated: Jul 5, 2026

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
Published on: May 31, 2016
Does dopamine still have a leading role in advanced Parkinson's disease after subthalamic stimulation?
Mazen Jabre1, George Nohra, Philippe Damier
1Parkinson, Memory and Movement Disorders Center, Notre Dame des Secours Hospital, Byblos/Jbail, Lebanon.
Abstract:
The role of endogenous dopamine in severe Parkinson's disease is often underestimated. We report on a case of acute general motor worsening induced by the ingestion of fluphenazine in a parkinsonian patient successfully treated with STN DBS. Other etiologies were ruled out. Clinical improvement was gradual and fully reversible 4 days after discontinuation of the antidopaminergic drug. We suggest that residual striatal and extrastriatal dopaminergic pathways still play a paramount role in mediating central neurotrasmissions that may take part in STN DBS's mechanism of action.
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