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Psychiatric Disorders and Apathy in Mixed Movement Disorders Linked to ADCY5 (MxMD-ADCY5)
Aurélie Méneret1,2, Clément Tarrano2,3, Asya Ekmen2
1Department of Neurology, DMU Neurosciences, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Summary
Psychiatric conditions like depression and anxiety are common in patients with ADCY5-related mixed movement disorders (MxMD-ADCY5). These findings suggest that mental health issues are a key part of the MxMD-ADCY5 disease spectrum.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Mixed movement disorders linked to ADCY5 (MxMD-ADCY5) are rare hyperkinetic movement disorders caused by ADCY5 gene variants.
- Psychiatric symptoms are increasingly suspected as part of the MxMD-ADCY5 phenotype.
Purpose of the Study:
- To investigate the prevalence of psychiatric comorbidities in patients diagnosed with MxMD-ADCY5.
- To compare psychiatric symptoms between patients with MxMD-ADCY5 and a control group.
Main Methods:
- Utilized the MINI International Neuropsychiatric Interview (MINI) for psychiatric diagnosis.
- Employed the Beck Depression Inventory (BDI-13), Hospital Anxiety and Depression Scale (HADS), and Starkstein Apathy Scale (SAS) for symptom assessment.
- Included 27 patients with MxMD-ADCY5 and 20 healthy controls in the study.
Main Results:
- A significantly higher proportion of patients (67%) exhibited psychiatric disorders compared to controls (15%).
- Anxiety and depression were the most prevalent psychiatric comorbidities in patients (33% and 44%, respectively).
- Patients with MxMD-ADCY5 showed elevated scores for depression, anxiety, and apathy compared to controls.
Conclusions:
- Depression, anxiety, and apathy are likely integral components of the phenotypic spectrum of MxMD-ADCY5.
- The study highlights the importance of screening for psychiatric comorbidities in individuals with MxMD-ADCY5.
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