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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Related Experiment Video

Updated: Jul 5, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

Androgen deficiency: effects on body composition.

Karen K Miller1

  • 1Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Bulfinch 457B, Boston, MA, 02114, USA. KKMiller@partners.org

Pituitary
|April 19, 2008
PubMed
Summary
This summary is machine-generated.

Testosterone

Related Experiment Videos

Last Updated: Jul 5, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

Area of Science:

  • Endocrinology
  • Body Composition Research

Background:

  • Androgen deficiency impacts body composition, decreasing lean mass and increasing fat mass in men.
  • Testosterone's anabolic effects on muscle are established, with mechanisms under investigation.
  • Limited data exist on androgen effects on female body composition due to lower endogenous levels.

Purpose of the Study:

  • To review published data on androgen deficiency and testosterone administration effects on body composition in men and women.
  • To discuss mechanisms of testosterone's anabolic effects on muscle.
  • To evaluate outcomes of testosterone administration in various hypogonadal states in men and explore data in women.

Main Methods:

  • Review of published data and randomized, placebo-controlled studies.
  • Analysis of experimental paradigms and clinical trial results.
  • Examination of studies in hypogonadal men (HIV, glucocorticoids, aging, obesity) and women with hypoandrogenemia.

Main Results:

  • Androgen deprivation decreases lean mass and increases fat mass in men; testosterone replacement reverses these.
  • Testosterone administration in hypogonadal men shows variable outcomes across different conditions.
  • Physiologic testosterone replacement in women with hypopituitarism increased skeletal muscle mass but not body fat.

Conclusions:

  • Androgens significantly influence body composition in men, with established replacement effects.
  • Further research is needed to fully understand androgen regulation of body composition in women.
  • Current understanding highlights sex differences in androgen impact on body composition.