Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcriptional regulation of the Arabidopsis transportome by salt stress and symbiosis with Serendipita indica.

Plant physiology and biochemistry : PPB·2026

Same author

Subungual Reactive Eccrine Syringofibroadenoma: A Case Report.

The American Journal of dermatopathology·2025

Same author

Relapsing meningoencephalitis of unknown origin in dogs results in changes in neuroanatomical localization, magnetic resonance imaging, and cerebrospinal fluid.

Journal of the American Veterinary Medical Association·2025

Same author

Skin manifestations uncover underlying Follicular helper T-cell lymphoma, angioimmunoblastic-type in an immunosuppressed patient.

Virchows Archiv : an international journal of pathology·2025

Same author

Chondrodermatitis Nodularis Helicis: Association with Higher Risk of Multimorbidity and Mortality in Middle-Aged Individuals and Implications for Prevention. An Observational Multicenter Retrospective Case-Control Investigation in Northern Spain.

Dermatology practical & conceptual·2025

Same author

Obesity, Diet, Physical Activity and Sleep in Argentinian Adolescents Before and After the COVID-19 Lockdown.

Journal of paediatrics and child health·2025

Same journal

Blastic Plasmacytoid Dendritic Cell Neoplasm.

Journal of cutaneous pathology·2026

Same journal

Atypical Grover Disease Associated With Merkel Cell Carcinoma: A Novel Paraneoplastic Presentation.

Journal of cutaneous pathology·2026

Same journal

Profile of a Founder: Herbert Zachareus Lund.

Journal of cutaneous pathology·2026

Same journal

The National Resident Match Program Arrives in Dermatopathology: 15 Years of Resilient Advocacy by the American Society of Dermatopathology's Fellowship Training Program Directors' Committee.

Journal of cutaneous pathology·2026

Same journal

Evaluating Large Language Models for Melanocytic Lesion Pathology Report Interpretation.

Journal of cutaneous pathology·2026

Same journal

An Atypical Skin Presentation of Adult-Onset Still's Disease With Histological Description: A Case Report.

Journal of cutaneous pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Leukemia cutis presenting as localized cutaneous hyperpigmentation.

Jorge Angulo¹, Rosario Haro, Elena González-Guerra

¹Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Journal of Cutaneous Pathology

|April 22, 2008

Summary

This summary is machine-generated.

Cutaneous hyperpigmentation can be an unusual initial sign of leukemia cutis, a rare skin manifestation of leukemia. This case highlights the importance of considering leukemia cutis in patients with unexplained skin discoloration.

Related Experiment Videos

Last Updated: Jul 5, 2026

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Area of Science:

Dermatology
Oncology
Hematology

Background:

Leukemia cutis typically presents as infiltrated plaques or nodules.
Cutaneous hyperpigmentation is often drug-induced in malignancy patients.
Biphenotypic leukemia is a rare hematologic malignancy.

Observation:

A 61-year-old male presented with new-onset cutaneous hyperpigmentation during chemotherapy for biphenotypic leukemia.
Skin lesions appeared as bluish to brownish irregular discolorations on the trunk and forehead.
The patient was asymptomatic with no palpable skin infiltration.

Findings:

Histopathology revealed dermal infiltrates of atypical basophilic cells.
Immunohistochemistry confirmed leukemia cutis with markers CD43, CD68, CD45RO, and myeloperoxidase.
This case represents cutaneous hyperpigmentation as the presenting sign of leukemia cutis.

Implications:

This presentation is rare, with no prior literature reports.
Highlights the need for dermatologic evaluation in malignancy patients with unusual skin changes.
Emphasizes considering leukemia cutis even with non-specific cutaneous findings.