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Updated: Jul 5, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
Published on: May 12, 2023
Congenital neutropenia syndromes
Kaan Boztug1, Karl Welte, Cornelia Zeidler
1Department of Pediatric Hematology/Oncology, Medical School Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.
Abstract:
Congenital neutropenia syndromes comprise a heterogeneous group of inherited disorders. Hereditary conditions associated with low neutrophil counts are persistent and need to be differentiated from neutropenia secondary to autoimmune processes or other pathologic conditions, such as myelodysplasia or leukemia. Clinically, congenital neutropenia is characterized by recurrent bacterial infections. Recently, several novel genetic defects were described in patients with congenital neutropenia, shedding light on the pathophysiology of these rare diseases.
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