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Apneusis responding to buspirone in multiple sclerosis.

R J O'Sullivan¹, I G Brown, M P Pender

¹Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|April 22, 2008

Summary

Apneusis, a prolonged inspiratory effort, is rarely seen in multiple sclerosis (MS). This study reports a case of episodic apneusis in an MS patient that improved with buspirone treatment.

Area of Science:

Neurology
Respiratory Medicine
Neuroimmunology

Background:

Apneusis is a rare respiratory disorder characterized by prolonged inspiratory spasms.
It typically results from bilateral lesions in the dorsal pons, often due to pontine infarction.
Multiple sclerosis (MS) is an infrequently reported cause of apneusis.

Observation:

A patient diagnosed with multiple sclerosis (MS) presented with episodic apneusis.
The patient's respiratory pattern exhibited prolonged inspiratory efforts characteristic of apneusis.

Findings:

The patient's apneusis episodes were episodic in nature.
Treatment with buspirone, a selective serotonin type 1A receptor agonist, led to a positive response.

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Implications:

This case suggests a potential therapeutic role for buspirone in managing apneusis associated with MS.
Further research may explore the efficacy of serotonin receptor agonists in treating respiratory disturbances in neuroinflammatory conditions.