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Updated: Jul 5, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Risk factors for in-stent restenosis after vertebral ostium stenting
Robert A Taylor1, Farhan Siddiq, M Fareed K Suri
1Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA. rataylor@umn.edu
Insights
Cobalt chromium stents reduced restenosis rates in vertebral arteries, while smoking increased the risk. This study analyzed stenting outcomes for vertebral ostium lesions.
Area of Science:
- Vascular surgery
- Interventional cardiology
- Biomaterials science
Background:
- Vertebral artery ostium lesions pose a risk for stroke.
- Stenting is a common treatment, but restenosis remains a concern.
- Identifying factors influencing restenosis is crucial for optimizing patient outcomes.
Purpose of the Study:
- To investigate the impact of vascular risk factors, vessel diameter, and stent type on restenosis rates after vertebral ostium stenting.
Main Methods:
- Retrospective analysis of 44 patients with 48 vertebral ostium lesions.
- Inclusion criteria: angiographic follow-up.
- Cox regression analysis for risk factor association; comparison of stent types for restenosis and lumen gain.
Main Results:
- Restenosis occurred in 48% of lesions at a mean follow-up of 7.7 months.
- Cigarette smoking was linked to higher restenosis rates (p=0.025).
- Cobalt chromium stents showed reduced restenosis and improved lumen gain compared to other stent types (p=0.002).
Conclusions:
- Cobalt chromium stents are associated with lower restenosis rates in vertebral arteries.
- Smoking is a significant risk factor for restenosis in this patient population.
Purpose:
To determine whether vascular risk factors, underlying vessel diameter, and/or the type of stent affect restenosis rates for vertebral ostium stents.
Methods:
A single-center retrospective analysis was conducted of 44 patients (31 men; mean age 61 years, range 32-81) who underwent stenting of 48 ostial lesions in the vertebral arteries between 1999 and 2005. Only patients who underwent angiographic follow-up were included in the analysis. Cox regression analysis was utilized for risk factor association with binary restenosis (> or =50% versus <50%). Stent types and stent categories were compared for differences in binary restenosis rates and lumen gain at follow-up angiography.
Results:
Twenty-three (48%) of 48 lesions had > or =50% stenosis at a mean follow-up of 7.7 months. Cigarette smoking was associated with higher binary restenosis rates (p=0.025), while hypertension, diabetes, hyperlipidemia, history of neck radiation, and known coronary artery and/or peripheral vascular disease were not. Reduced binary restenosis rates and improved lumen gain were seen in cobalt chromium balloon-expandable stents compared to non-cobalt chromium stents (p=0.002 and p=0.002, respectively), stainless steel balloon-expandable stents (p=0.005 and p=0.005), and the S670 stent (p=0.069 and p=0.069). The size of stent used was not associated with risk of restenosis (p=0.756).
Conclusions:
Cobalt chromium stents were associated with reduced restenosis, while smoking was associated with increased restenosis risk.
