Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A randomized crossover clinical trial of multi-periscopic and Fresnel peripheral prism glasses for hemianopia.

Optometry and vision science : official publication of the American Academy of Optometry·2026

Same author

Effect of Binocularity and Depth on Static and Dynamic Accommodation Responses in Young Children.

Investigative ophthalmology & visual science·2026

Same author

Longitudinal Evaluation of Static and Dynamic Accommodation in Young Children.

Investigative ophthalmology & visual science·2025

Same author

Longitudinal measures of pupil barycenter and estimation of angle kappa in young children.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2025

Same author

IMI-Interventions for Controlling Myopia Onset and Progression 2025.

Investigative ophthalmology & visual science·2025

Same author

Editorial: Differences between emmetropic and myopic eyes: implications for myopia development, its progression, and ocular health.

Frontiers in medicine·2025

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

Monocular fixation with the optic nerve head: a case report.

Fuensanta A Vera-Diaz¹, Eli Peli

¹Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA. fuensanta.veradiaz@schepens.harvard.edu

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)

|April 23, 2008

Summary

This study documents a rare case of left esotropia where the patient uses the optic nerve head (ONH) instead of the fovea for stable monocular fixation, a unique ocular motor adaptation.

More Related Videos

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Jul 5, 2026

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Published on: March 3, 2023

Area of Science:

Ophthalmology
Neuroscience
Visual Science

Background:

Esotropia (ET) is a common form of strabismus characterized by inward turning of the eyes.
Typically, visual fixation is achieved using the fovea, the central area of the retina with the highest visual acuity.

Observation:

A case report of an 80-year-old male with lifelong left esotropia.
Monocular fixation measurements revealed stable fixation within the left optic nerve head (ONH) area, deviating from typical foveal fixation.
Fixation remained stable across various target sizes and gaze positions, confirmed by MP-1 retinal tracking and visuoscopy.

Findings:

This is the first documented case of an abnormally developed monocular ocular motor system where fixation is centered on the ONH.
The principal visual direction and zero retinomotor value were shifted from the fovea to the ONH.
While direct visual input from the ONH is unlikely, the patient may use peri-papillary visual information or scattered light around the ONH margin for positional awareness.

Implications:

This case challenges conventional understanding of visual fixation mechanisms in strabismus.
The findings suggest that extraretinal information combined with abnormal oculocentric direction can stabilize fixation.
The study proposes using retinal perimetry for documenting eccentric fixation in strabismus cases.