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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
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Published on: October 13, 2016

Behaviour in amyotrophic lateral sclerosis.

Zoe C Gibbons1, Anna Richardson, David Neary

  • 1Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

Patients with amyotrophic lateral sclerosis (ALS) can exhibit behavioral changes similar to frontotemporal dementia (FTD). These changes, particularly in affect and social behavior, are important for managing ALS patients.

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Area of Science:

  • Neuroscience
  • Neurology
  • Behavioral Science

Background:

  • Accumulating evidence suggests a link between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
  • Systematic exploration of behavioral changes in ALS patients has been limited.
  • Understanding behavioral overlap is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the presence and nature of behavioral changes in ALS patients.
  • To determine if these changes resemble those observed in FTD.
  • To explore the relationship between behavioral alterations and neuroimaging findings.

Main Methods:

  • Administered an informant-based, semi-structured behavioral interview to carers of 16 consecutive ALS patients.
  • The interview was specifically designed to detect FTD-like behavioral changes.
  • Correlated behavioral findings with SPECT abnormalities in frontal and/or temporal lobes.

Main Results:

  • Behavioral changes varied among ALS patients, ranging from none to a spectrum similar to FTD.
  • Most common changes included alterations in affect and social behavior.
  • Other observed changes included sensory processing differences, eating abnormalities, stereotypies, and compulsions.
  • SPECT abnormalities in frontal and/or temporal lobes mirrored the observed behavioral changes.

Conclusions:

  • Behavioral changes characteristic of FTD can be present in ALS patients, even in a small cohort.
  • Early detection of these behavioral changes is vital for effective ALS patient management.
  • The findings underscore the complex relationship between ALS and FTD.