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Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury
J Benavides1, A Dubois, B Scatton
1Synthélabo Recherche, Bagneux Cédex, France.
Abstract:
The concentration of peripheral type benzodiazepine binding sites (PTBS) in the brain parenchyma is greatly increased following brain lesions, reflecting the glial reaction and/or presence of hematogenous cells. Thus, PTBS density is a sensitive and reliable marker of brain injury in a large number of experimental models (ischemia, trauma, excitotoxic lesions, brain tumors) and equivalent human neuropathological conditions. PTBS density can be measured using specific radioligands and a conventional binding technique, or by quantitative autoradiography in tissue sections.
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