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Experimental autoimmune encephalomyelitis (EAE)
1University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Current Protocols in Neuroscience
|April 23, 2008
Abstract:
The procedures described in this unit utilize murine models exclusively since murine EAE often results in a relapsing/remitting disease, similar to the early phase of most MS patients. EAE in the Lewis rat is a monophasic illness in which animals experience a single episode of paralysis from which most recover completely. This unit presents two methods for inducing EAE in mice: active induction and adoptive transfer.

