Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 5, 2026

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

Place preference test in rodents.

Sylvain Roux1, Christelle Froger, Roger D Porsolt

  • 1Porsolt and Partners Pharmacology, Boulogne Billancourt, France.

Current Protocols in Neuroscience
|April 23, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transitional initiatives for advancing the phasing out of the use of animals for drug and chemical safety testing: The IHI VICT3R project for reducing the use of animals by implementing virtual control groups.

NAM journal·2026
Same author

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium.

British journal of pharmacology·2026
Same author

A Male Mouse Model of WIN 55,212-2 Self-Administration to Study Cannabinoid Addiction.

Bio-protocol·2026
Same author

Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.

Gut microbes·2026
Same author

Sex and dose-dependent effects of cannabidiol on cocaine consumption in mice.

Translational psychiatry·2026
Same author

Prenatal-lactational alcohol exposure induces sex-specific CX<sub>3</sub>CL1/CX<sub>3</sub>CR1 dysregulation linked to neuroendocrine imbalance and cardiovascular risk.

Brain, behavior, and immunity·2026
Same journal

Simultaneous Ca<sup>2+</sup> Imaging and Optogenetic Stimulation of Cortical Astrocytes in Adult Murine Brain Slices.

Current protocols in neuroscience·2020
Same journal

Automated Two-Chamber Operon ID/ED Task for Mice.

Current protocols in neuroscience·2020
Same journal

A Guide to Fluorescence Lifetime Microscopy and Förster's Resonance Energy Transfer in Neuroscience.

Current protocols in neuroscience·2020
Same journal

Development, Screening, and Validation of Camelid-Derived Nanobodies for Neuroscience Research.

Current protocols in neuroscience·2020
Same journal

Recombinant Antibodies in Basic Neuroscience Research.

Current protocols in neuroscience·2020
Same journal

Automated Quantification of Mitochondrial Fragmentation in an In Vitro Parkinson's Disease Model.

Current protocols in neuroscience·2020
See all related articles

This study details the conditioned place preference (CPP) behavioral model for assessing drug reward properties in rats and mice. It outlines procedures adaptable for genetically modified mouse lines, enhancing its utility in neuroscience research.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Animal Models

Background:

  • Conditioned place preference (CPP) is a key behavioral paradigm.
  • CPP measures the rewarding effects of drugs by associating them with environmental cues.
  • Advancements in genetic engineering provide new tools for behavioral research.

Purpose of the Study:

  • To provide detailed procedures for implementing the CPP model.
  • To adapt the CPP paradigm for use in both rats and mice.
  • To facilitate research using genetically modified mouse lines in addiction studies.

Main Methods:

  • Detailed protocols for conducting CPP experiments in rodents.
  • Adaptations for testing place preference in mice, including genetically modified strains.

More Related Videos

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
08:29

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
08:29

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

  • Standardized procedures for environmental conditioning and behavioral assessment.

    • Main Results:

    • The study provides a comprehensive guide to the CPP methodology.
    • Procedures are validated for reliable assessment of drug-induced reward.
    • The methods accommodate the use of diverse rodent models.

    Conclusions:

    • The CPP model remains a valuable tool for studying drug reward.
    • The described procedures enhance the applicability of CPP across different rodent models.
    • This work supports further investigation into the neurobiological basis of reward using genetic models.